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Orthopaedic Clinic

Gene therapy in Orthopedics
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Gene transfer technologies:


Viral Vectors:


            Adeno viruses

            Adeno associated viruses.

            Retroviral vectors.

            Herpes Virus



Non Viral vectors:


            Naked DNA injection.


            Gene Gun


            Polymer DNA complexes


Potential orthopedic uses:


Heriditary disorders:

  • Osteogenesis imperfecta,
  • familial osteoarthritis,
  • osteopetrosis,
  • some crystal arthropathies,
  • certain forms of osteoporosis,
  • muscular dystrophy
  • mucopolysaccharidosis,
  • hemophilia,
  • Marfan's syndrome,
  • Ehlers-Danlos syndrome,
  • and other connective tissue hereditary disorders

Acquired disorders:


  • Arthritis,
  • collagen diseases (systemic lupus erythematosus, scleroderma, and others),
  • cartilage damage,
  • ligament and tendon repair,
  • fractures (especially delayed union, nonunion, and spinal fusion),
  •  infections such as TB and coccidiodomycosis,
  • some forms of osteoporosis,
  • osteosarcomas
  • and other tumors

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