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Orthopaedic Clinic

Chemical mediators of pain

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Neurogenic mediators (Generated by Neuronal cell bodies):
 
Substance P
Angiotensin II
Neurotensin
Gelanin
Enkephalin
Dynorphin
Gastrin related peptides.
Somatostatin
Cholecystokinin like substance.
Vasoactive intestinal peptides.
Calcitonin gene related products.
 
 
Non Neurogenic mediators of pain:
 
Histamine
Serotonin
Bradykinin
PG E2
PG E1
Leukotriense
Acetyl choline
di HETE.
 
 

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